Ovarian cancer

@article{Jayson2014OvarianC,
  title={Ovarian cancer},
  author={Gordon C. Jayson and Elise C. Kohn and Henry C Kitchener and Jonathan A. Ledermann},
  journal={The Lancet},
  year={2014},
  volume={384},
  pages={1376-1388}
}
Epithelial ovarian cancer is the commonest cause of gynaecological cancer-associated death. The disease typically presents in postmenopausal women, with a few months of abdominal pain and distension. Most women have advanced disease (International Federation of Gynecology and Obstetrics [FIGO] stage III), for which the standard of care remains surgery and platinum-based cytotoxic chemotherapy. Although this treatment can be curative for most patients with early stage disease, most women with… Expand
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Epithelial ovarian cancer
TLDR
Urgent progress is needed to develop evidence and consensus-based treatment guidelines for each subgroup, and requires close international cooperation in conducting clinical trials through academic research groups such as the Gynecologic Cancer Intergroup. Expand
Management and Treatment of Recurrent Epithelial Ovarian Cancer.
TLDR
New targeted treatments such as antiangiogenic drugs, poly(adenosine diphosphate-ribose) polymerase inhibitors, and immune checkpoint inhibitors offer potential for improved survival. Expand
Early onset neutropenia: a useful predictor of chemosensitivity and favorable prognosis in patients with serous ovarian cancer
TLDR
Early onset neutropenia may be potentially used as a potential indicator for chemosensitivity and favorable prognosis of SOC in patients who underwent six cycles of carboplatin plus paclitaxel adjuvant chemotherapy following primary cytoreductive surgery. Expand
Honokiol and Magnolol Induce Apoptosis and Cell Cycle Arrest in Human Ovarian Cancer Cells
Epithelial ovarian cancer is the fourth most common cause of cancer-related death among women worldwide. Over 220,000 woman are diagnosed with epithelial ovarian cancer every year, with the incidence… Expand
Frontline Maintenance Treatment for Ovarian Cancer
TLDR
Much has been learnt from the success and challenges of these treatments that have in the last few years which led to significant reduction in disease recurrence, changed the guidelines for treatment, and established a new paradigm for the treatment of ovarian cancer. Expand
Mitochondrial integration and ovarian cancer chemotherapy resistance.
TLDR
The cellular interactive regulatory network surrounding mitochondria is discussed, the mechanisms of tumor cell survival under chemotherapy under chemotherapy are elucidated, and potential means of interfering with mitochondrial function as a novel anti-cancer therapy are discussed. Expand
Clinicopathological predictors of chemoresponsiveness in epithelial ovarian cancer: a preliminary institutional study
TLDR
Complete response during treatment and optimal surgery significantly increases OS, CSS, and TTR, and preoperative CA125 and lymph node removal during surgery may be predictive of complete treatment response. Expand
Chemotherapy is not necessary for early-stage serous and endometrioid ovarian cancer after undergoing comprehensive staging surgery
TLDR
It was demonstrated that adjuvant chemotherapy was unnecessary for patients with early-stage serous and endometrioid ovarian cancer after they underwent comprehensive staging surgery, and the age was associated with poor prognosis. Expand
Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy.
TLDR
Several membrane receptors associated with pivotal cellular processes and often aberrantly overexpressed in ovarian cancer cells have emerged as potential targets for receptor-mediated therapeutic strategies including specific agents and multifunctional delivery systems based on ligand-receptor binding. Expand
Ovarian Cancer: An Integrated Review.
TLDR
An overview of the risk factors, modifiable and non-modifiable, for ovarian cancer as well as prevention, diagnostic, treatment, and long-term survivorship concerns are provided. Expand
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