Ovarian action of leptin: effects on insulin-like growth factor-I-stimulated function of granulosa and thecal cells.

@article{Spicer2000OvarianAO,
  title={Ovarian action of leptin: effects on insulin-like growth factor-I-stimulated function of granulosa and thecal cells.},
  author={Leon J. Spicer and Connie S. Chamberlain and Cristina C. Francisco},
  journal={Endocrine},
  year={2000},
  volume={12 1},
  pages={53-9}
}
To test the hypothesis that leptin signals metabolic information to the reproductive system in cattle by directly affecting IGF-I-induced ovarian cell function, granulosa and thecal cells from bovine ovarian follicles were cultured for 2 d in serum-free medium with added hormones. Recombinant human leptin at 30 and 300 ng/mL had no effect on basal thecal cell steroidogenesis or thecal cell numbers. However, 300 but not 30 ng/mL of leptin attenuated (p < 0.05) luteinizing hormone-induced… CONTINUE READING
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