Corpus ID: 17073424

Ovarian Carcinoma Xenografts Tumor Burden and Prolongs Survival of Mice Bearing Human A Synthetic Matrix Metalloproteinase Inhibitor Decreases Updated

@inproceedings{Davies2006OvarianCX,
  title={Ovarian Carcinoma Xenografts Tumor Burden and Prolongs Survival of Mice Bearing Human A Synthetic Matrix Metalloproteinase Inhibitor Decreases Updated},
  author={B. Davies and P. Brown and N. East and Michael J. 'rimmin and F. Balkwill},
  year={2006}
}
We have examined the effect of a synthetic low-molecular-weight ma trix metalloproteinase inhibitor, [4-(A'-hydroxyamino)-2/?-isobutyl-3S(thiopen-2-ylthiomethyl)-succinyl]-i.-phenylalanine-iV-methylamide (BB94), on human ovarian carcinoma xenografts growing in nude mice. The xenografts grew as thick intraperitoneal mucinous ascites containing freefloating tumor cell clumps. The ascites increased in volume, causing death approximately 3 weeks after introduction. Treatment with BB-94 caused… Expand

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