Ovarian Cancer Cell Lines that Overexpress erbB-2 Apoptosis-inducing Ligand-mediated Apoptosis in Breast and (Herceptin) Enhances Tumor Necrosis Factor-related Down-Regulation of the erbB-2 Receptor by Trastuzumab

Abstract

We investigated whether combined treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and trastuzumab could enhance the specific killing of cells that overexpress the erbB-2 receptor. The combination resulted in an enhancement of TRAIL-mediated apoptosis in all cell lines overexpressing erbB-2 receptor compared with either reagent… (More)

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