Ovarian 17-ketosteroid reductase deficiency as a possible cause of polycystic ovarian disease.

@article{Toscano1990Ovarian1R,
  title={Ovarian 17-ketosteroid reductase deficiency as a possible cause of polycystic ovarian disease.},
  author={V. Toscano and R. Balducci and P. Bianchi and A. Mangiantini and F. Sciarra},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={71 2},
  pages={
          288-92
        }
}
The deficiency of ovarian 17-ketosteroid reductase (17-KSR) was recently discovered to be a possible cause of polycystic ovarian disease (PCOD) in hirsute women. Forty three patients with PCOD (age range, 18-38 yr) were reevaluated to search for a hormonal pattern that might suggest an ovarian 17-KSR deficiency. Androstenedione, testosterone, FSH, LH, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate were evaluated basally on the day 17 of the menstrual cycle, when present, and after… Expand
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