Ovalbumin injected with complete Freund's adjuvant stimulates cytolytic responses.

@article{Ke1995OvalbuminIW,
  title={Ovalbumin injected with complete Freund's adjuvant stimulates cytolytic responses.},
  author={Yong Ke and Yongjun Li and Judith A. Kapp},
  journal={European journal of immunology},
  year={1995},
  volume={25 2},
  pages={549-53}
}
CD8+ cytotoxic T lymphocytes (CTL) recognize antigens (Ag) associated with class I major histocompatibility complex (MHC) molecules. Endogenously synthesized protein Ag are processed into peptides in the cytoplasm and transported to the endoplasmic reticulum where they are bound by class I proteins. Exogenous Ag do not enter the class I processing pathway of most cells and thus do not activate CD8+ CTL. Nevertheless, several investigators have reported that immunization with exogenous Ag can… CONTINUE READING
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