Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

@article{Lemire1991OvalCP,
  title={Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.},
  author={Joan M Lemire and Nobuyoshi Shiojiri and Nelson Fausto},
  journal={The American journal of pathology},
  year={1991},
  volume={139 3},
  pages={535-52}
}
Oval cells may function as facultative liver stem cells and tumor progenitors in liver carcinogenesis. The authors determined whether oval cells proliferate and if small hepatocytes might be generated from epithelial cell progenitors in noncarcinogenic liver injury. The authors found that oval cells similar to those detected in early carcinogenesis proliferate in response to D-galactosamine (GaIN). Oval cells expressed gamma-glutamyl transpeptidase activity, bile duct-type cytokeratins and… CONTINUE READING