Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1beta production and deficient apoptosis of rheumatoid arthritis monocytes.

@article{Meusch2009OutsidetoinsideST,
  title={Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1beta production and deficient apoptosis of rheumatoid arthritis monocytes.},
  author={Undine Meusch and Manuela Rossol and Christoph W. Baerwald and Sunna Hauschildt and Ulf Wagner},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 9},
  pages={
          2612-21
        }
}
OBJECTIVE Monocytes are a major source of proinflammatory cytokines in rheumatoid arthritis (RA), and inhibitors of monocytic cytokines are highly efficient agents for treatment of the disease. The aim of this study was to analyze the effects of a therapeutic anti-tumor necrosis factor alpha (anti-TNFalpha) antibody on monocytes from patients with RA and healthy control subjects. METHODS Peripheral blood monocytes from patients with RA and healthy control subjects were incubated in the… CONTINUE READING
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