Outside-in signaling by lipopolysaccharide through a tailless integrin.

  title={Outside-in signaling by lipopolysaccharide through a tailless integrin.},
  author={Robin R. Ingalls and M. Amin Arnaout and Douglas T Golenbock},
  journal={Journal of immunology},
  volume={159 1},
Ligand binding to integrins activates intracellular signaling pathways that coordinate and regulate a variety of cellular responses. There is evidence to suggest that the cytoplasmic tails play a key role in several of these signaling events. We sought to determine whether the beta2 integrin complement receptor type 3 (CR3; CD11b/CD18), a receptor for LPS, could initiate an intracellular signal in the absence of its cytoplasmic domains. Expression of full length CR3 in a Chinese hamster ovary… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…