Outside-in signaling by lipopolysaccharide through a tailless integrin.

@article{Ingalls1997OutsideinSB,
  title={Outside-in signaling by lipopolysaccharide through a tailless integrin.},
  author={Robin R. Ingalls and M. Amin Arnaout and Douglas T Golenbock},
  journal={Journal of immunology},
  year={1997},
  volume={159 1},
  pages={433-8}
}
Ligand binding to integrins activates intracellular signaling pathways that coordinate and regulate a variety of cellular responses. There is evidence to suggest that the cytoplasmic tails play a key role in several of these signaling events. We sought to determine whether the beta2 integrin complement receptor type 3 (CR3; CD11b/CD18), a receptor for LPS, could initiate an intracellular signal in the absence of its cytoplasmic domains. Expression of full length CR3 in a Chinese hamster ovary… CONTINUE READING

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