Outpatient antibiotic use in Europe and association with resistance: a cross-national database study

@article{Goossens2005OutpatientAU,
  title={Outpatient antibiotic use in Europe and association with resistance: a cross-national database study},
  author={Herman Goossens and Matus Ferech and Robert Vander Stichele and Monique Elseviers},
  journal={The Lancet},
  year={2005},
  volume={365},
  pages={579-587}
}
BACKGROUND Resistance to antibiotics is a major public-health problem and antibiotic use is being increasingly recognised as the main selective pressure driving this resistance. [...] Key MethodMETHODS We investigated outpatient antibiotic use in 26 countries in Europe that provided internationally comparable distribution or reimbursement data, between Jan 1, 1997, and Dec 31, 2002, by calculating the number of defined daily doses (DDD) per 1000 inhabitants per day, according to WHO anatomic therapeutic…Expand
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TLDR
The paediatric antibiotic prescription rate is substantially higher in Viareggio compared with Funen, confirming possible overuse and misuse of antibiotics in the Italian paediatric population.
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References

SHOWING 1-10 OF 32 REFERENCES
Variation in antibiotic use in the European Union
TLDR
There was profound variation in use of different classes of antibiotics, and detailed knowledge of antibiotic use is necessary to implement national strategies for optimum antibiotic use, and to address the threat posed by resistant microorganisms.
Defined daily doses of antimicrobials reflect antimicrobial prescriptions in ambulatory care.
TLDR
The results confirm the relevance of the number of DDDs per 1000 inhabitant-days as a measurement unit to compare outpatient antimicrobial use among countries or regions.
European surveillance of antimicrobial consumption (ESAC): data collection performance and methodological approach.
TLDR
In cross-national comparisons of antibiotic consumption in Europe, methodological rigour in correcting for various sources of bias and checking the validity of ATC/DDD assignment is needed.
Importance of Local Variations in Antibiotic Consumption and Geographical Differences of Erythromycin and Penicillin Resistance in Streptococcus pneumoniae
TLDR
A geographical analysis of how commonly prescribed oral antibiotics are quantitatively and qualitatively responsible for the different local rates of erythromycin and penicillin resistance in Streptococcus pneumoniae in Spain is presented shows that consumption of once-a-day macrolides was key for local erystromycin resistance variations.
European antimicrobial resistance surveillance as part of a community strategy
TLDR
The results show that in Europe antimicrobial resistance of S. pneumoniae to penicillin is correlated with use of betalactam antibiotics and macrolides, and efforts to control antimicrobial use and misuse could be stimulated and monitored in Europe.
A European study on the relationship between antimicrobial use and antimicrobial resistance.
TLDR
Results show that in Europe antimicrobial resistance of S. pneumoniae to penicillin is correlated with use of beta-lactam antibiotics and macrolides.
Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction
TLDR
Results show that a huge decrease in antibiotic prescribing does not necessarily reduce resistance within a useful time, and the main reason seems to be the genetic linkage of the index resistance to other resistance determinants.
Trends in antimicrobial drug use in the community--France, 1981-1992.
TLDR
The proper use of cephalosporins must be encouraged, and vigilance is required in view of the increased improper use of fluoroquinolones, mainly for respiratory tract infections with a presumed viral etiology.
Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice.
BACKGROUND Community prescribing of antibiotics has decreased substantially in the UK in recent years. We examine the association between pneumonia mortality and recent changes in community-based
Effect of βlactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study
TLDR
Reduction in β lactam use could quickly reduce the carriage rates of penicillin resistant pneumococci in early childhood, in view of the propensity of these organisms to be spread among children in the community.
...
1
2
3
4
...