Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients

@inproceedings{Gaykalova2015OutlierAD,
  title={Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients},
  author={Daria A. Gaykalova and Rajita Vatapalli and Yingying Wei and Hua-Ling Tsai and Hao Wang and Chi Zhang and Patrick T. Hennessey and Theresa Guo and Marietta L Tan and Ryan Li and Julie Ahn and Zubair Khan and William H Westra and Justin A Bishop and David Zaboli and Wayne M Koch and Tanbir Khan and Michael F. Ochs and Joseph A. Califano and K. D. Lo},
  booktitle={PloS one},
  year={2015}
}
Head and Neck Squamous Cell Carcinoma (HNSCC) is the fifth most common cancer, annually affecting over half a million people worldwide. Presently, there are no accepted biomarkers for clinical detection and surveillance of HNSCC. In this work, a comprehensive genome-wide analysis of epigenetic alterations in primary HNSCC tumors was employed in conjunction with cancer-specific outlier statistics to define novel biomarker genes which are differentially methylated in HNSCC. The 37 identified… CONTINUE READING
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Activation of the NOTCH pathway in head and neck cancer

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