Outgrowth of human liver metastases after resection of the primary colorectal tumor: a shift in the balance between apoptosis and proliferation.

@article{Peeters2006OutgrowthOH,
  title={Outgrowth of human liver metastases after resection of the primary colorectal tumor: a shift in the balance between apoptosis and proliferation.},
  author={Charlotte F J M Peeters and Robert M. W. de Waal and Theo Wobbes and Johan R Westphal and Theo Ruers},
  journal={International journal of cancer},
  year={2006},
  volume={119 6},
  pages={1249-53}
}
Rapid outgrowth of metastases after removal of the primary tumor has been described in several mouse models. Loss of primary tumor-induced inhibition of angiogenesis in the metastases has been suggested as the underlying cause. Accordingly, we recently demonstrated that vascular density in human colorectal liver metastases increases after primary tumor resection. Here, we investigate whether this increase in vascular density has, in its turn, effects on the tumor growth of the liver metastases… CONTINUE READING