Outflanking RANK with a Designer Antagonist Cytokine

  title={Outflanking RANK with a Designer Antagonist Cytokine},
  author={Chih-wen Ou-yang and Richard M Siegel},
  journal={Science Signaling},
Members of the tumor necrosis factor (TNF) superfamily of cytokines are noncovalently linked trimers that play important roles in regulating the immune system and have emerged as successful therapeutic targets in various rheumatic and autoimmune conditions. Traditionally, antibodies to cytokines or receptor-Fc fusion proteins have been used to block signaling by TNF family cytokines. In this issue of Science Signaling, Warren et al. have taken a new approach to blocking the action of the TNF… CONTINUE READING