Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.

@article{Grimm2004OutersurfacePC,
  title={Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.},
  author={Dorothee Grimm and Kit Tilly and Rebecca Byram and Philip E Stewart and Jonathan G. Krum and Dawn M Bueschel and T. Schwan and Paul F. Policastro and Abdallah F. Elias and Patricia A Rosa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 9},
  pages={3142-7}
}
Environmentally responsive synthesis of surface proteins represents a hallmark of the infectious cycle of the Lyme disease agent, Borrelia burgdorferi. Here we created and analyzed a B. burgdorferi mutant lacking outer-surface protein C (OspC), an abundant Osp that spirochetes normally synthesize in the tick vector during the blood meal and down-regulate after transmission to the mammal. We demonstrate that B. burgdorferi strictly requires OspC to infect mice but not to localize or migrate… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
180 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 180 extracted citations

Similar Papers

Loading similar papers…