Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC.

@article{Gilmore1996OuterSP,
  title={Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC.},
  author={Robert D Gilmore and Karina Kappel and Martin Christopher Dolan and Thomas R. Burkot and Benjamin J. M. Johnson},
  journal={Infection and immunity},
  year={1996},
  volume={64 6},
  pages={
          2234-9
        }
}
Outbred mice were immunized with the soluble fraction of a crude Escherichia coli lysate containing either recombinant outer surface protein C (OspC or P39 of Borrelia burgdorferi B31 (low passage). Following seroconversion, the mice were challenged with an infectious dose of B. burgdorferi B31 via the natural transmission mode of tick bite. Three mice immunized with P39 were not protected; however, all 12 of the recombinant OspC-immunized mice were protected from infection as assayed by… CONTINUE READING

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