Outer retinal necrosis due to a strain of varicella-zoster virus resistant to acyclovir, ganciclovir, and sorivudine.

@article{Wunderli1996OuterRN,
  title={Outer retinal necrosis due to a strain of varicella-zoster virus resistant to acyclovir, ganciclovir, and sorivudine.},
  author={W Wunderli and R Miner and J Wintsch and S von Gunten and H H Hirsch and B Hirschel},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1996},
  volume={22 5},
  pages={864-5}
}
  • W Wunderli, R Miner, +3 authors B Hirschel
  • Published 1996 in
    Clinical infectious diseases : an official…
Theinhibitory activityof acycloviris basedon itsphosphorylation by theviralthymidine kinase(TK).AfterpatientswithAIDSreceive long-termtreatmentwith acyclovirfor the controlof infections with herpes zoster and herpes simplex viruses, resistant isolates may appear. Most of the resistant strains are either deficient in TK or inducea TK withan alteredsubstratespecificity [I, 2]. Foscarnethas a differentinhibitionmechanismand is the established alternative in these cases [3]. However, its toxicity… CONTINUE READING