Outer pore architecture of a Ca2+-selective TRP channel.

  title={Outer pore architecture of a Ca2+-selective TRP channel.},
  author={Thomas Voets and A. CecileJ.W. Janssens and Guy Droogmans and Bernd Nilius},
  journal={The Journal of biological chemistry},
  volume={279 15},
The TRP superfamily forms a functionally important class of cation channels related to the product of the Drosophila trp gene. TRP channels display an unusual diversity in activation mechanisms and permeation properties, but the basis of this diversity is unknown, as the structure of these channels has not been studied in detail. To obtain insight in the pore architecture of TRPV6, a Ca(2+)-selective member of the TRPV subfamily, we probed the dimensions of its pore and determined pore-lining… CONTINUE READING


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