Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

@article{Ding2017OuterNM,
  title={Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture},
  author={Zhao-Ying Ding and Ying-Hsuan Wang and Yu-Cheng Huang and Myong-Chol Lee and Min-Jen Tseng and Ya-Hui Chi and Min-Lang Huang},
  journal={The Journal of Cell Biology},
  year={2017},
  volume={216},
  pages={2827 - 2841}
}
Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one, Kuduk (Kud), which can reside at the outer nuclear membrane and is required for the development of Drosophila melanogaster ovarian follicles and NE morphology of myonuclei. Kud associates with LINC complex components in an evolutionarily conserved manner… 
SUN/KASH interactions facilitate force transmission across the nuclear envelope
TLDR
In vivo functions of conserved interfaces revealed by crystal structures are tested for conserved aromatic residues at the -7 position of the C-termini of KASH proteins and conserved disulfide bonds in LINC complexes, which play important roles in force transmission across the nuclear envelope.
Chain reaction: LINC complexes and nuclear positioning
TLDR
New aspects of LINC complex regulation are highlighted revealing that the interplay between SUN and KASH partners can strongly influence how the nucleus functionally engages with different branches of the cytoskeleton.
Chain reaction : LINC complexes and nuclear positioning
TLDR
New aspects of LINC complex regulation are highlighted revealing that the interplay between SUN and KASH partners can strongly influence how the nucleus functionally engages with different branches of the cytoskeleton.
Drosophila emerins control LINC complex localization and transcription to regulate myonuclear position
TLDR
Data indicate emerin-dependent regulation of Klarsicht levels in the nuclear envelope is a critical determinant of nuclear position, which is necessary for the proper movement of myonuclei.
tmem-258 is dispensable for both nuclear anchorage and migration in C. elegans
TLDR
This data indicates that the number of mislocalized hyp7 nuclei in the dorsal cord in TMEM-258 is likely to be higher than previously thought, due to the high number of syncytial hyp 7 nuclei clustering together.

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