Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

  title={Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture},
  author={Zhao-Ying Ding and Ying-Hsuan Wang and Yu-cheng Huang and Myong-Chol Lee and Min-Jen Tseng and Y. Chi and Min-Lang Huang},
  journal={The Journal of Cell Biology},
  pages={2827 - 2841}
  • Zhao-Ying Ding, Ying-Hsuan Wang, +4 authors Min-Lang Huang
  • Published 2017
  • Biology, Medicine
  • The Journal of Cell Biology
  • Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one, Kuduk (Kud), which can reside at the outer nuclear membrane and is required for the development of Drosophila melanogaster ovarian follicles and NE morphology of myonuclei. Kud associates with LINC complex components in an evolutionarily conserved manner… CONTINUE READING
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