Outer membrane lipoprotein VacJ is required for the membrane integrity, serum resistance and biofilm formation of Actinobacillus pleuropneumoniae.

@article{Xie2016OuterML,
  title={Outer membrane lipoprotein VacJ is required for the membrane integrity, serum resistance and biofilm formation of Actinobacillus pleuropneumoniae.},
  author={Fang Xie and Gang Li and Wan-Jiang Zhang and Yanhe Zhang and Long Yin Zhou and Shuanghong Liu and Si-guo Liu and Chunlai Wang},
  journal={Veterinary microbiology},
  year={2016},
  volume={183},
  pages={1-8}
}
The outer membrane proteins of Actinobacillus pleuropneumoniae are mediators of infection, acting as targets for the host's defense system. The outer membrane lipoprotein VacJ is involved in serum resistance and intercellular spreading in several pathogenic bacteria. To investigate the role of VacJ in the pathogenicity of Actinobacillus pleuropneumoniae, the vacJ gene-deletion mutant MD12 ΔvacJ was constructed. The increased susceptibility to KCl, SDS plus EDTA, and several antibiotics in the… CONTINUE READING
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