Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B.

  title={Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B.},
  author={Alexander J F Egan and Nicolas L Jean and Alexandra Koumoutsi and Catherine Bougault and Jacob Biboy and Jad Sassine and Alexandra S. Solovyova and Eefjan Breukink and Athanasios Typas and Waldemar Vollmer and Jean-Pierre Simorre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 22},
Bacteria surround their cytoplasmic membrane with an essential, stress-bearing peptidoglycan (PG) layer. Growing and dividing cells expand their PG layer by using membrane-anchored PG synthases, which are guided by dynamic cytoskeletal elements. In Escherichia coli, growth of the mainly single-layered PG is also regulated by outer membrane-anchored lipoproteins. The lipoprotein LpoB is required for the activation of penicillin-binding protein (PBP) 1B, which is a major, bifunctional PG synthase… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 21 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

The elongated molecular structure of the outer-membrane activator of peptidoglycan synthesis LpoA: Implications for PBP1A-stimulation

NL Jean
View 1 Excerpt

Structure of Neisseria meningitidis lipoprotein GNA1162.

Acta crystallographica. Section F, Structural biology and crystallization communications • 2013
View 1 Excerpt

The physiology of bacterial cell division.

Annals of the New York Academy of Sciences • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…