Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks

@article{Neelakanta2007OuterSP,
  title={Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks},
  author={Girish Neelakanta and Xin Li and Utpal Pal and Xianzhong Liu and Deborah S. Beck and Kathleen Deponte and Durland Fish and Fred S. Kantor and Erol Fikrig},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={115 - 125}
}
Survival of Borrelia burgdorferi in ticks and mammals is facilitated, at least in part, by the selective expression of lipoproteins. Outer surface protein (Osp) A participates in spirochete adherence to the tick gut. As ospB is expressed on a bicistronic operon with ospA, we have now investigated the role of OspB by generating an OspB-deficient B. burgdorferi and examining its phenotype throughout the spirochete life cycle. Similar to wild-type isolates, the OspB-deficient B. burgdorferi were… CONTINUE READING