Outer Segment Formation of Transplanted Photoreceptor Precursor Cells

@inproceedings{Eberle2012OuterSF,
  title={Outer Segment Formation of Transplanted Photoreceptor Precursor Cells},
  author={Dominic Eberle and Thomas Kurth and Tiago F. Santos-Ferreira and John Wilson and Denis Corbeil and Marius Ader},
  booktitle={PloS one},
  year={2012}
}
Transplantation of photoreceptor precursor cells (PPCs) into the retina represents a promising treatment for cell replacement in blinding diseases characterized by photoreceptor loss. In preclinical studies, we and others demonstrated that grafted PPCs integrate into the host outer nuclear layer (ONL) and develop into mature photoreceptors. However, a key feature of light detecting photoreceptors, the outer segment (OS) with natively aligned disc membrane staples, has not been studied in detail… CONTINUE READING

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