Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib.

  title={Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib.},
  author={Preetesh Jain and Michael J Keating and William G Wierda and Zeev Estrov and Alessandra Ferrajoli and Nitin Jain and Binsah George and Danelle Frances James and Hagop M Kantarjian and Jan A Burger and Susan M O'Brien},
  volume={125 13},
Ibrutinib is a Bruton tyrosine kinase inhibitor approved for the treatment of patients with relapsed refractory chronic lymphocytic leukemia (RR-CLL). We describe the characteristics, causes of discontinuation, and outcomes in patients who discontinued treatment with ibrutinib. One hundred twenty-seven patients were enrolled in various clinical trials of ibrutinib, with or without rituximab, at our center. Thirty-three (26%) patients have discontinued ibrutinib to date. The majority of those… CONTINUE READING
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