Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action.

@article{Chen2017OutcomesOC,
  title={Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action.},
  author={Jinling Chen and Yuejin Liang and Panpan Yi and Lanman Xu and Hal K. Hawkins and Shannan L. Rossi and Lynn Soong and Jiyang Cai and Ramkumar Menon and Jiaren Sun},
  journal={Cell reports},
  year={2017},
  volume={21 6},
  pages={
          1588-1599
        }
}
Zika virus (ZIKV) infection during pregnancy in humans results in intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we found that fetus-derived type I interferon (IFN-I) signaling can enhance anti-ZIKV responses and provide clinical benefits to the fetus. Because IFN-λ shares signaling cascades and antiviral functions with IFN-I, we investigated the in vivo effects of IFN-λ in ZIKV-infected pregnant mice. IFN-λ administration during mid-pregnancy reduced ZIKV burden… CONTINUE READING
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