• Corpus ID: 27654464

Outcomes in Type 1 Diabetic Pregnancies

  title={Outcomes in Type 1 Diabetic Pregnancies},
  author={Megan Jensen and Peter Damm and Lars Moelsted-Pedersen and Per Glud Ovesen and Greg Westergaard and Margrethe Moeller and Henning Beck-Nielsen},
RESEARCH DESIGN AND METHODS — This nationwide prospective multicenter study took place in eight Danish centers treating pregnant women with type 1 diabetes during 1993–1999. A total of 990 women with 1,218 pregnancies and delivery after 24 weeks (n 1,215) or early termination due to severe congenital malformations (n 3) were included. Data were collected prospectively by one to three caregivers in each center and reported to a central registry. 

Tables from this paper

Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study.

Pregnancies of both type 1 and 2 diabetes carry an increased risk for foetal development of PVH compared with those with gestational diabetes, and close monitoring of these pregnancies may prevent perinatal catastrophes.

Outcomes of pregnancies in women with pre‐gestational diabetes mellitus and gestational diabetes mellitus; a population‐based study in New South Wales, Australia, 1998–2002

To determine population‐based rates and outcomes of pre‐gestational diabetes mellitus (pre‐GDM) and gestational Diabetes mellitus in pregnancy in pregnancy, a large number of women were diagnosed with either pre‐ or during pregnancy.

Stillbirth in the Pregnancy Complicated by Diabetes

The purpose of this article is to review the literature on the epidemiology, pathophysiology, and prevention, as well as future research, of diabetes-associated perinatal mortality.

Potentially modifiable risk factors of preterm delivery in women with type 1 and type 2 diabetes

The presence of preeclampsia, higher positive ultrasound estimated fetal weight deviation at 27 gestational weeks and higher gestational weight gain were independent potentially modifiable risk factors for preterm delivery in this cohort of women with pre-existing diabetes.

A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes

  • M. HodE. Mathiesen P. Damm
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2014
In conclusion, IDet is as well tolerated as NPH as regards perinatal outcomes in pregnant women with type 1 diabetes and no safety issues were identified.

Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes–obstetrical clinics in Dublin in three university teaching hospitals (1995–2006)

Pregnancy outcomes in T1DMP remain worse than in the general population despite management in combined obstetric/diabetes clinics in a single centre using similar management protocols, and these outcomes in the study population of T2DMP in Dublin appear better than some previously reported studies.

Trends in maternal BMI, glycaemic control and perinatal outcome among type 1 diabetic pregnant women in 1989–2008

Self-reported pregestational BMI has increased and glycaemic control during the second half of pregnancy has deteriorated and poor glycaemia control seems to be associated with the observed increases in adverse obstetric and perinatal outcomes.

Impact of Carbohydrate Counting Method during Pregnancy in Women with Pregestational Diabetes Mellitus: A Controlled Clinical Trial.

Both methods of nutritional guidance contributed to the reduction of postprandial glycemia of women and no differences were observed for maternal and perinatal outcomes.

Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes

In this large multicentre study, women using insulin pumps in pregnancy had lower HbA1c without increased risk of severe hypoglycaemia or diabetic ketoacidosis but no improvement in other pregnancy outcomes.

Magnitude of Pre-Existing Diabetes Mellitus Among Pregnant Women in Southern Ethiopia: A Cross-Sectional Study

The magnitude of pre-existing DM is comparable with International Diabetes Federation Estimate to Ethiopia in the study area and is associated with increased risk of abortion and fetal macrosomia.



French multicentric survey of outcome of pregnancy in women with pregestational diabetes.

Pregnancies in women with diabetes are still poorly planned and complicated by higher rates of perinatal mortality and major congenital malformations, and the influence of preconception care 10 years after the St Vincent's declaration.

St Vincent’s Declaration 10 years on: outcomes of diabetic pregnancies

Aims To monitor pregnancies in women with pregestational Type 1 diabetes for pregnancy loss, congenital malformations and fetal growth parameters, in a geographically defined area in the north west

Obstetric and diabetic care for pregnancy in diabetic women: 10 years outcome analysis, 1985–1995

Ten‐year outcome analysis of all pregnancies in diabetic women in a population of 1.5 million people finds no change in the number of women diagnosed with diabetes or in the quality of their quality of life.

Prospective population based survey of outcome of pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994

Diabetic pregnancy remains a high risk state with perinatal mortality and fetal malformation rates much higher than in the background population.

Glycaemic control during early pregnancy and fetal malformations in women with Type I diabetes mellitus

Even a slightly raised HbA1 c during early pregnancy in women with Type I diabetes carries an increased risk for fetal malformations, therefore normoglycaemia should be strived for during earlyregnancy.

Macrosomia despite good glycaemic control in Type I diabetic pregnancy; results of a nationwide study in The Netherlands

Third trimester HbA1c was the most powerful predictor, but its predictive capacity was weak, and future research should focus on new more detailed glucose monitoring techniques as well as to alternative factors to reduce macrosomia.

Relationship between haemoglobin A1c in early type 1 (insulin-dependent) diabetic pregnancy and the occurrence of spontaneous abortion and fetal malformation in Sweden

It is concluded that poor metabolic control in early pregnancy contributes to an increased risk of both spontaneous abortion and fetal malformation.

Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy.

In type 1 diabetic pregnancy, the risk of SH is increased already before pregnancy and rises further during the first trimester, and a history of SH before gestation, longer duration of diabetes, an HbA1c level < or = 6.5%, and a higher total daily insulin dose were risk indicators predictive for SH during thefirst trimester.

HbA1c levels are significantly lower in early and late pregnancy.

There is a need to establish the reference range of HbA1c during normal pregnancy with an internationally recognized Diabetes Control and Complications Trial (DCCT)-aligned method.

Normal fetal growth evaluated by longitudinal ultrasound examinations.