Outcomes following virological failure and predictors of switching to second-line antiretroviral therapy in a South African treatment program.

@article{Johnston2012OutcomesFV,
  title={Outcomes following virological failure and predictors of switching to second-line antiretroviral therapy in a South African treatment program.},
  author={Victoria J Johnston and Katherine L. Fielding and Salome Charalambous and Gavin John Churchyard and Andrew Phillips and Alison D Grant},
  journal={Journal of acquired immune deficiency syndromes},
  year={2012},
  volume={61 3},
  pages={370-80}
}
OBJECTIVES Without resistance tests, deciding which patients with virological failure should switch to second-line antiretroviral therapy (ART) is difficult. The factors influencing this decision are poorly understood. We assess predictors of switching regimens after virological failure. DESIGN Retrospective cohort study using clinical data from a South African ART program with 6-monthly viral load (VL) monitoring. METHODS We constructed a dataset of patient visits occurring following first… CONTINUE READING

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