Outcomes after resection of cholangiocellular carcinoma.

Abstract

BACKGROUND Cholangiocellular carcinoma (CCC) is a rare primary liver malignancy that arises from intrahepatic bile duct canaliculi and presents as a liver mass. Our purpose is to report operative morbidity and mortality and to determine long-term survival after resection for CCC. METHODS Retrospective review of 31 consecutive patients who underwent resection during a 20-year period. RESULTS Thirty-day hospital mortality was 3%, and postoperative morbidity was 38%. Kaplan-Meier 5-year survival was 35%; mean survival was 37 months; absolute 5-year survival was 33%. Mean survival in stages I, II, IIIA, and IIIC were 57, 33, 26, and 14 months, respectively (P = 0.03 comparing I to >I). Recurrence occurred in 18 patients; 89% were in the liver. Carbohydrate antigen 19-9 >100 U/mL was found to be an indicator of poor prognosis (P = 0.009). CONCLUSIONS Resection for CCC can be performed with acceptable morbidity and mortality rates and results in good survival and cure. Hepatic recurrence is common. Carbohydrate antigen 19-9 may be useful in determining prognosis.

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@article{Huang2004OutcomesAR, title={Outcomes after resection of cholangiocellular carcinoma.}, author={Jasmine L Huang and Thomas R Biehl and Faye T Lee and Peter W. Zimmer and John A. Ryan}, journal={American journal of surgery}, year={2004}, volume={187 5}, pages={612-7} }