Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region

@article{Pui2002OutcomeOT,
  title={Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region},
  author={Ching-Hon Pui and Paul S. Gaynon and James M. Boyett and J. M. Chessells and Bruce M. Camitta},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={1909-1915}
}
BACKGROUND The prognosis and optimum treatment of childhood acute lymphoblastic leukaemia (ALL) with abnormalities of chromosomal band 11q23 are controversial. We aimed to identify prognostic factors that might help in planning future therapy, and to assess the effectiveness of haemopoietic stem-cell transplantation in patients with the t(4;11) translocation, which is associated with a particularly poor outcome. METHODS We reviewed data on 497 children and young adults who had ALL with… CONTINUE READING
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