Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR–ABL-positive acute lymphoblastic leukemia—retrospective analysis of Polish Adult Leukemia Group (PALG)

@article{WrzesieKu2006OutcomeOT,
  title={Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR–ABL-positive acute lymphoblastic leukemia—retrospective analysis of Polish Adult Leukemia Group (PALG)},
  author={Agata Wrzesień-Kuś and Tadeusz Robak and Agnieszka Pluta and Malgorzata Zwolinska and Ewa Wawrzyniak and Agnieszka Wierzbowska and Aleksander Bartłomiej Skotnicki and Beata Jakubas and Jerzy Hołowiecki and Katarzyna Nowak and Kazimierz Kuliczkowski and Grzegorz Mazur and Olga Haus and Anna Dmoszyńska and Maria Adamczyk-Cioch and Wieslaw Wiktor Jędrzejczak and Monika Paluszewska and Lech Konopka and Grazyna Pałynyczko},
  journal={Annals of Hematology},
  year={2006},
  volume={85},
  pages={366-373}
}
Patients with Philadelphia chromosome-positive (Ph+) and/or BCR–ABL+ acute lymphoblastic leukemia (ALL) have extremely poor prognoses. Most of these patients have additional, heterogenous karyotype abnormalities, the majority of which have uncertain clinical significance. In this study we analyzed the clinical characteristics, karyotype abnormalities, and outcome of 77 patients with Ph+ and/or BCR–ABL+ ALL registered in Poland in 1997–2004. In 31/55 patients with known karyotype, the sole t(9… CONTINUE READING