Outcome of patients with primary refractory diffuse large B cell lymphoma after R-CHOP treatment

@article{Hitz2015OutcomeOP,
  title={Outcome of patients with primary refractory diffuse large B cell lymphoma after R-CHOP treatment},
  author={Felicitas Hitz and Joseph M. Connors and Randy D. Gascoyne and Paul Hoskins and Alden A Moccia and Kerry J. Savage and Laurie H. Sehn and Tamara N Shenkier and Diego Villa and Richard Klasa},
  journal={Annals of Hematology},
  year={2015},
  volume={94},
  pages={1839-1843}
}
Primary refractory diffuse large B cell lymphoma (DLBCL) following R-CHOP chemotherapy is a major concern. We identified 1126 patients with DLBCL treated with R-CHOP from 2000 to 2009, of whom 166 (15 %) had primary refractory disease. Of the 75/166 (45 %) who were age <70 years and had been planned for stage-directed curative therapy, 43 (57 %) were primary nonresponders and 32 (43 %) relapsed within 3 months of completing R-CHOP. Thirty of 75 (40 %) patients had serious comorbidity and organ… CONTINUE READING
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Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d’Etude des Lymphomes de l’Adulte

  • P Feugier, A Van Hoof, +13 authors B Coiffier
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