Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction.

@article{Jander2011OutcomeOP,
  title={Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction.},
  author={Nikolaus Jander and Jan Minners and Ingar Holme and Eva Gerdts and Kurt Boman and Philippe Brudi and John Boyd Chambers and Kenneth Egstrup and Yrj{\"o} Antero Kes{\"a}niemi and William Malbecq and Christoph A. Nienaber and Simon G. Ray and Anne Bj\orhovde Rosseb\o and Terje Rolf Pedersen and Terje Skj{\ae}rpe and Ronnie B. Willenheimer and Kristian Wachtell and F W Neumann and Christa Gohlke-Baerwolf},
  journal={Circulation},
  year={2011},
  volume={123 8},
  pages={887-95}
}
BACKGROUND Retrospective studies have suggested that patients with a low transvalvular gradient in the presence of an aortic valve area < 1.0 cm² and normal ejection fraction may represent a subgroup with an advanced stage of aortic valve disease, reduced stroke volume, and poor prognosis requiring early surgery. We therefore evaluated the outcome of patients with low-gradient "severe" stenosis (defined as aortic valve area < 1.0 cm² and mean gradient ≤ 40 mm Hg) in the prospective Simvastatin… CONTINUE READING
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