Outcome of patients with acute myeloid leukemia with monosomal karyotype who undergo hematopoietic cell transplantation.

@article{Fang2011OutcomeOP,
  title={Outcome of patients with acute myeloid leukemia with monosomal karyotype who undergo hematopoietic cell transplantation.},
  author={Min Fang and Barry E Storer and Elihu Estey and Megan K. D. Othus and Lisa Zhang and Brenda M Sandmaier and Frederick R Appelbaum},
  journal={Blood},
  year={2011},
  volume={118 6},
  pages={1490-4}
}
Monosomal karyotype (MK), defined as ≥ 2 autosomal monosomies or a single monosomy in the presence of other structural abnormalities, was confirmed by several studies to convey an extremely poor prognosis in patients with acute myeloid leukemia (AML) with a 4-year overall survival after diagnosis of < 4%. A recent investigation by the Southwest Oncology Group found that the only MK(+) patients alive and disease free > 6 years from diagnosis received allogeneic hematopoietic cell transplantation… CONTINUE READING