Outcome of clonal hemophagocytic lymphohistiocytosis: analysis of 32 cases.

  title={Outcome of clonal hemophagocytic lymphohistiocytosis: analysis of 32 cases.},
  author={Shinsaku Imashuku and Shigeyoshi Hibi and Yasuhiro Tabata and Eiichi Itoh and Tohru Hashida and Kentaro Tsunamoto and Koichi Ishimoto and Fumio Kawano},
  journal={Leukemia & lymphoma},
  volume={37 5-6},
We studied the impact of clonality, determined by analysis of Epstein-Barr virus genome termini, T-cell receptor genes and clonal chromosomal abnormality, on the clinical outcome in 32 patients with hemophagocytic lymphohistiocytosis (HLH). Of the cases studied, 23 cases were EBV-clonal, 15 cases were TCR-clonal and 7 cases were cytogenetically clonal. Thirty patients were treated with immuno-chemotherapy and/or multiagents' chemotherapy and 4 received bone marrow transplantation. All 7 cases… CONTINUE READING


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