Outcome of acute promyelocytic leukemia (APL) in children and adolescents: an analysis in two consecutive trials of the European APL Group.

@article{Bally2012OutcomeOA,
  title={Outcome of acute promyelocytic leukemia (APL) in children and adolescents: an analysis in two consecutive trials of the European APL Group.},
  author={C{\'e}cile Bally and Jehane Fadlallah and Guy G Leverger and Yves Bertrand and Alain Robert and Andr{\'e} Baruchel and Agn{\`e}s Guerci and Christian R{\'e}cher and Emmanuel Raffoux and X. Thomas and Thierry Leblanc and Nadia Idres and Bruno Cassinat and Norbert Vey and Christine Chomienne and Herv{\'e} Dombret and M Rosa Sen{\'a}n Sanz and Pierre Fenaux and Lionel Ad{\`e}s},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2012},
  volume={30 14},
  pages={1641-6}
}
PURPOSE Acute promyelocytic leukemia (APL) is rare in children. All-trans-retinoic acid (ATRA) combined with chemotherapy, the reference treatment of APL, is generally considered to produce similar results in children and adults. However, previously published childhood APL studies have generally analyzed all patients age < 18 years as a group, without further dividing according to age. PATIENTS AND METHODS We compared disease characteristics and outcomes of children (age ≤ 12 years… CONTINUE READING

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