Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry

@article{Andrade2006OutcomeOA,
  title={Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry},
  author={Ra{\'u}l J Andrade and Mar{\'i}a Isabel Lucena and Neil Kaplowitz and Beatriz Garc{\'i}a-Muņoz and Yolanda Borraz and Ketevan Pachkoria and Miren Garc{\'i}a‐Cort{\'e}s and M. Carmen Fern{\'a}ndez and Gloria Pelaez and Luis Rodrigo and Jos{\'e} Ant{\'o}nio Duran and Joan Costa and Ramón Planas and Anabel Barriocanal and Carlos Guarner and Manuel Romero-G{\'o}mez and Teresa Muñoz-Yagüe and Javier Salm{\'e}ron and Ram{\'o}n Hidalgo},
  journal={Hepatology},
  year={2006},
  volume={44}
}
A chronic adverse reaction may occur in some instances of drug‐induced liver injury (DILI), even despite drug cessation. In our study, we obtained records from a Spanish registry and evaluated cases of DILI with biochemical evidence of long‐term damage. Chronic outcome was defined as a persistent biochemical abnormality of hepatocellular pattern of damage more than 3 months after drug withdrawal or more than 6 months after cholestatic/mixed damage. Data on 28 patients with a chronic clinical… Expand
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