Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry

  title={Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry},
  author={R. Andrade and M. Lucena and N. Kaplowitz and B. Garc{\'i}a-Muņoz and Y. Borraz and K. Pachkoria and M. Garc{\'i}a‐Cort{\'e}s and M. Fern{\'a}ndez and G. Pelaez and L. Rodrigo and J. A. Duran and J. Costa and R. Planas and A. Barriocanal and C. Guarner and M. Romero-G{\'o}mez and T. Muņoz-Yag{\"u}e and J. Salmer{\'o}n and R. Hidalgo},
  • R. Andrade, M. Lucena, +16 authors R. Hidalgo
  • Published 2006
  • Medicine
  • Hepatology
  • A chronic adverse reaction may occur in some instances of drug‐induced liver injury (DILI), even despite drug cessation. In our study, we obtained records from a Spanish registry and evaluated cases of DILI with biochemical evidence of long‐term damage. Chronic outcome was defined as a persistent biochemical abnormality of hepatocellular pattern of damage more than 3 months after drug withdrawal or more than 6 months after cholestatic/mixed damage. Data on 28 patients with a chronic clinical… CONTINUE READING
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