Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival.

@article{Forestier2008OutcomeOE,
  title={Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival.},
  author={Erik Forestier and M. Marshall Heyman and Mette Klarskov Andersen and Kirsi Autio and Elisabeth Blennow and Georg H. Borgstr{\"o}m and Irina Golovleva and Sverre Heim and Kristina Heinonen and Randi Hovland and J{\'o}hann Heidar J{\'o}hannsson and Gitte Kerndrup and Ann Nordgren and Richard Rosenquist and Birgitta Swolin and Bertil Johansson},
  journal={British journal of haematology},
  year={2008},
  volume={140 6},
  pages={665-72}
}
The prognostic impact of t(12;21)(p13;q22) [ETV6/RUNX1 fusion] in paediatric acute lymphoblastic leukaemia (ALL) has been extensively debated, particularly with regard to the frequency of late relapses and appropriate treatment regimens. We have retrospectively collected 679 ALLs with known ETV6/RUNX1 status, as ascertained by fluorescence in situ hybridization or reverse-transcription polymerase chain reaction, treated according to the Nordic Society of Paediatric Haematology and Oncology -ALL… CONTINUE READING
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