Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol.

@article{Patrick2014OutcomeOD,
  title={Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol.},
  author={Katharine L Patrick and Rachel Wade and Nicholas Goulden and Clare Rowntree and Rachael M Hough and Anthony V Moorman and Christopher D. Mitchell and A. H. Vora},
  journal={British journal of haematology},
  year={2014},
  volume={165 4},
  pages={552-5}
}
We report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal residual disease… CONTINUE READING