Outcome of Diffuse Axonal Injury Treated Conservatively

  title={Outcome of Diffuse Axonal Injury Treated Conservatively},
  author={Rajgopal J. Totla and Ishtyaque Ansari and Kunal Mehta},
Diffuse axonal injury is a brain injury in which damage in the form of extensive lesions in white matter tracts occurs over a widespread area. DAI is one of the most common and devastating types of traumatic brain injury and major cause of unconsciousness and persistent vegetative state after head trauma. It occurs in about half of all cases of severe head trauma. This study was undertaken to investigate the correlation between the degrees of injuries based on MRI findings and the mean time… 

Outcome of diffuse axonal injury in moderate and severe traumatic brain injury

It is concluded that the severity of the traumatic head injury and the grade of the DAI impact the outcome, and Survivors require long-term hospitalization and rehabilitation to improve their chances of recovery.



Challenges of Diffuse Axonal Injury Diagnosis

Diffuse axonal injury (DAI), one of the most important causes of cognitive dysfunction after TBI, occurs in a more widespread pattern in certain regions of the brain than the localized zone of focal injuries.

The Correlation of MRI Findings to Outcome in Diffuse Axonal Injury Patients

It is important and reasonable to take brain MRI to identify the brainstem lesions in any cases of suspicious diffuse axonal injury, and it should remind that the diffuseAxonal injury with stem lesion has worse prognosis.

Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases

The available evidence indicates that DAI in human beings occurs at the time of head injury and is not due to complicating factors such as hypoxia, brain swelling, or raised intracranial pressure.

Diffuse axonal injury and traumatic coma in the primate

It is concluded that axonal damage produced by coronal head acceleration is a major cause of prolonged traumatic coma and its sequelae and is identical to that seen in severe head injury in humans.

Prognostic Factors in Patients with Diffuse Axonal Injury

The findings suggest that when such clinical settings are evident physicians should be borne in mind that these will play unfavorable role to patients in terms of outcome and prognosis and thus careful and prompt attention should be given to these patients.

Clinical Analysis of the Prognosis of the Patients with Cerebral Diffuse Axonal Injuries, Based on Gradient-echo MR Imaging.

The poor outcome group showed more numbers of lesion and more frequent involvement of brain stem and corpus callosum than favorable outcome group, and Gradient-echo MR imaging seems to have predictive value for clinical outcome in patients with DAI.

Influence of the type of intracranial lesion on outcome from severe head injury.

Patients were categorized according to a simple classification system comprising seven lesion types, each of which was further subdivided into two GCS score ranges (3 to 5 and 6 to 8).

Diffuse Axonal Injury in Head Trauma

Diffuse axonal injury is one of the most common and important pathologic features of traumatic brain injury and is poorly defined as clinical syndrome, but future advancements in the diagnosis and treatment will be dependent on the collective understanding of injury biomechanics, temporal axonal pathophysiology, and its role in patient outcome.


  • S. Strich
  • Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1956
The findings in the brains of five patients who' survived a closed head injury in a more or less decerebrate and extremely demented state, for five to 15 months are reported.

Clinical outcome after head injury in children

The outcome mainly depended on the initial coma grade, but the duration of coma or advanced age were also negative factors for outcome.