Outcome of 40 adults aged from 18 to 55 years with acute lymphoblastic leukemia treated with double-delayed intensification pediatric protocol.

@article{Haat2011OutcomeO4,
  title={Outcome of 40 adults aged from 18 to 55 years with acute lymphoblastic leukemia treated with double-delayed intensification pediatric protocol.},
  author={St{\'e}phanie Ha{\"i}at and Zora Marjanovic and Simona Lapusan and Anne Vekhoff and Bernard Rio and Elise Corre and Sophie Dimicoli and Pierre Hirsch and Jean-Pierre Marie and Ollivier Legrand},
  journal={Leukemia research},
  year={2011},
  volume={35 1},
  pages={66-72}
}
Adolescents ALL have a better outcome when treated with pediatric protocol compared to adult protocol. We have tested the feasibility of pediatric protocol to treat 40 consecutive adults ALL. DFS and OS were 73±7%, and 72±7%, and were significantly longer in patients under 40 yo (81±9% vs 51±15%, p=0.05 [DFS] and 83±7.8% vs 45±15%, p=0.003 [OS], respectively) or cortico/chemo-sensitive (86±9% vs 36±16%, p=0.001 [DFS] and 95±4.4% vs 28±13%, p<0.0001 [OS]) than in other patients. Overall… CONTINUE READING

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