Outcome from molecular adsorbent recycling system (MARS™) liver dialysis following drug‐induced liver failure

@article{Lee2005OutcomeFM,
  title={Outcome from molecular adsorbent recycling system (MARS{\texttrademark}) liver dialysis following drug‐induced liver failure},
  author={Kan-Hoe Lee and Margaret Kwee-Hiang Lee and Dede Selamat Sutedja and Seng-Gee Lim},
  journal={Liver International},
  year={2005},
  volume={25}
}
Abstract: Rationale: Fulminant liver failure from drug ingestion is associated with a high mortality, and the introduction of liver transplantation has improved the mortality significantly if done in a timely fashion. Recently, molecular adsorbent recycling system (MARS™) liver dialysis has been introduced as a support for liver failure with varying results. We review our experience with drug‐induced liver failure and the impact of MARS™ liver dialysis on the outcome, in a setting where… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Despite the lack of large multicentre randomized trials on the use of MARS™ in patients with acute liver failure, the literature shows clinical and biological benefit from this technique, and it is potentially a promising treatment for Patients with acute poisoning from drugs that have high protein-binding capacity and are metabolized by the liver.
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TLDR
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TLDR
Better prognostic markers than hepatic encephalopathy should be used to assess the need for liver transplantation in acute liver failure, especially in patients with a completely necrotic liver.
Survival predictors in patients treated with a molecular adsorbent recirculating system.
TLDR
MARS treatment appears to be ineffective in AOCLF with end-stage cirrhosis without an LTX option, and the etiology of liver disease was the most important prognostic factor.
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