Outcome and prognostic markers in severe drug‐induced liver disease

@article{Bjrnsson2005OutcomeAP,
  title={Outcome and prognostic markers in severe drug‐induced liver disease},
  author={Einar S. Bj{\"o}rnsson and Rolf Olsson},
  journal={Hepatology},
  year={2005},
  volume={42}
}
The combination of high aminotransferases (hepatocellular injury) and jaundice has been reported to lead to a mortality rate of 10% to 50% for different drugs, a phenomenon known as “Hy's rule.” However, Hy's rule has never been validated, and limited data exist on predictors for outcome in hepatocellular and other forms of drug‐induced liver disease. All reports of suspected hepatic adverse drug reactions received by the Swedish Adverse Drug Reactions Advisory Committee (1970‐2004) were… 
Drug Induced Liver Injury at a Tertiary Hospital in India: Etiology, Clinical Features and Predictors of Mortality.
INTRODUCTION AND AIMS Drug-induced liver injury (DILI) is rare; however, it is one of the important causes of acute liver failure which results in significant morbidity or mortality. MATERIAL AND
Drug Induced Liver Injury at a Tertiary Hospital in India: Etiology, Clinical Features and Predictors of Mortality.
INTRODUCTION AND AIMS Drug-induced liver injury (DILI) is rare; however, it is one of the important causes of acute liver failure which results in significant morbidity or mortality. MATERIAL AND
Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes
TLDR
It is concluded that step-down steroid therapy for DILI improved curative effect, shortened disease course, and was safe.
Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry
TLDR
Patients with cholestatic/mixed injury were more prone to chronicity than patients with hepatocellular injury, and cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage.
Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset.
TLDR
The profile of liver injury at presentation, initial severity, patient's race, and medical comorbidities are important determinants of the likelihood of death/transplantation or persistent liver injury within 6 months of DILI onset.
Drug induced liver injury is associated with high mortality—A study from a tertiary care hospital in Pakistan
TLDR
A close control of clinical and biochemical parameters are required to prevent and monitor DILI, especially in patients taking ATDs in the authors' region, where more than a quarter of patients died during hospital stay.
Idiosyncratic drug-induced liver injury: an overview
TLDR
Over the next decade, the combination of accurate case ascertainment of DILI via clinical networks and the application of genomics and proteomics will hopefully lead to accurate prediction of risk of D ILI, so that pharmacotherapy can be optimised with avoidance of adverse hepatic events.
The long-term follow-up after idiosyncratic drug-induced liver injury with jaundice.
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