Outcome and prognostic markers in severe drug‐induced liver disease

@article{Bjrnsson2005OutcomeAP,
  title={Outcome and prognostic markers in severe drug‐induced liver disease},
  author={Einar S. Bj{\"o}rnsson and Rolf Olsson},
  journal={Hepatology},
  year={2005},
  volume={42}
}
The combination of high aminotransferases (hepatocellular injury) and jaundice has been reported to lead to a mortality rate of 10% to 50% for different drugs, a phenomenon known as “Hy's rule.” However, Hy's rule has never been validated, and limited data exist on predictors for outcome in hepatocellular and other forms of drug‐induced liver disease. All reports of suspected hepatic adverse drug reactions received by the Swedish Adverse Drug Reactions Advisory Committee (1970‐2004) were… Expand
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