Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial.

@article{Roy2005OutcomeAF,
  title={Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial.},
  author={Anindita Roy and Anna Cargill and Sharon Love and Anthony V Moorman and Sara J. Stoneham and Anita Y. N. Lim and Phil J Darbyshire and Donna L Lancaster and Ian Hann and T. J. Eden and Vaskar Saha},
  journal={British journal of haematology},
  year={2005},
  volume={130 1},
  pages={67-75}
}
A retrospective analysis of children with first relapse of acute lymphoblastic leukaemia (ALL), treated on the UKALL R2 protocol at four different hospitals, between June 1995 and December 2002 was performed. Of the 150 children 139 (93%) achieved a second complete remission. The overall survival (OS) and event-free survival (EFS) for the whole group was 56% and 47% respectively. The duration of first complete remission and immunophenotype, but not sites of relapse, were predictive for survival… CONTINUE READING