Outcome Assessment of Minimizing Vancomycin Monitoring and Dosing Adjustments

@article{Karam1999OutcomeAO,
  title={Outcome Assessment of Minimizing Vancomycin Monitoring and Dosing Adjustments},
  author={Christine M. Karam and Peggy S. McKinnon and Melinda M. Neuhauser and Michael Joseph Rybak},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1999},
  volume={19}
}
An approach to minimize monitoring of vancomycin therapy was evaluated in 120 patients, and results were compared with data from 120 patients in whom vancomycin therapy was monitored and adjusted based on serum peak and trough concentrations and traditional pharmacokinetic methods. Patients dosed by the nomogram (NM) had regimens adjusted based on actual body weight, estimated creatinine clearance, and a targeted trough concentration of 5–20 μg/ml. A single trough serum concentration was drawn… Expand
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TLDR
New vancomycin dosage guidelines have been developed that achieve trough concentrations of 10-15 mg/L earlier and more consistently than current guidelines. Expand
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TLDR
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