Outcome Assessment of Minimizing Vancomycin Monitoring and Dosing Adjustments

@article{Karam1999OutcomeAO,
  title={Outcome Assessment of Minimizing Vancomycin Monitoring and Dosing Adjustments},
  author={Christine M. Karam and Peggy S. McKinnon and Melinda M. Neuhauser and Michael Joseph Rybak},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1999},
  volume={19}
}
An approach to minimize monitoring of vancomycin therapy was evaluated in 120 patients, and results were compared with data from 120 patients in whom vancomycin therapy was monitored and adjusted based on serum peak and trough concentrations and traditional pharmacokinetic methods. Patients dosed by the nomogram (NM) had regimens adjusted based on actual body weight, estimated creatinine clearance, and a targeted trough concentration of 5–20 μg/ml. A single trough serum concentration was drawn… 

[Therapeutic monitoring of vancomycin in critical care pediatric patients].

D dosage regime of vancomycin in patients from a pediatric intensive care unit, register values of plasmatic concentrations and determine the regimes necessary to reach therapeutic troughs are described, being able to suppose that equal schemes of administration could be implemented more frequently.

Evaluation of Treatment Courses When Vancomycin Is Given Every 8 Hours in Adult Patients

An increase in the percentage of trough levels >20 mg/L later during treatment courses of vancomycin IV Q8H with a relatively small corresponding increase in vancomYcin dose is observed.

Evaluation of Vancomycin Dosing and Monitoring in Adult Medicine Patients

The implementation of a vancomycin empiric dosing protocol and monitoring tool had a significant impact on the initial dose, dosing interval, and trough concentrations in adult medicine patients.

Vancomycin Dosing and Monitoring: Critical Evaluation of the Current Practice

  • F. Elbarbry
  • Medicine, Biology
    European Journal of Drug Metabolism and Pharmacokinetics
  • 2017
Two user-friendly and scientifically based dosing strategies are proposed to improve the efficiency of vancomycin dosing while avoiding the risk of nephrotoxicity and minimizing the cost of therapeutic drug monitoring.

Approaching and analyzing a large literature on vancomycin monitoring and pharmacokinetics.

Existing evidence does not seem to support routine serum therapeutic monitoring for vancomycin dosing to improve clinical outcome in patients with sufficient creatinine clearance, however, regular monitoring to allow for dose adjustment in Patients with renal dysfunction and those receiving other nephrotoxic agents is currently recommended due to the potential side effects of excessive vancomYcin dosed in this population subset.

Optimisation of Vancomycin Regimen in Neutropenic Haematological Patients with Normal Renal Function

Since the volume of distribution and/or clearance of vancomycin can be increased in patients with haematological malignancies and normal renal function, increasing the number of daily doses from two to four (with the same total daily dose) may increase t > MIC, an important determinant of van comycin efficacy.

Hospitalized Patients With and Without Hemodialysis Have Markedly Different Vancomycin Pharmacokinetics: A Population Pharmacokinetic Model-Based Analysis

Dosing nomogram based on these covariate relationships may potentially help in accurate dosing of vancomycin.

Evaluation of a vancomycin dosing nomogram in achieving high target trough concentrations in Taiwanese patients.

Development and evaluation of vancomycin dosage guidelines designed to achieve new target concentrations.

New vancomycin dosage guidelines have been developed that achieve trough concentrations of 10-15 mg/L earlier and more consistently than current guidelines.

Recommendations for Monitoring Serum Vancomycin Concentrations

The available evidence on the efficacy and toxicity of different concentrations of vancomycin is examined and guidelines for therapeutic drug monitoring in patients receiving vancomYcin therapy are presented.
...

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