Outcome--adaptive randomization: is it useful?

@article{Korn2011OutcomeadaptiveRI,
  title={Outcome--adaptive randomization: is it useful?},
  author={Edward L. Korn and Boris Freidlin},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 6},
  pages={
          771-6
        }
}
Outcome-adaptive randomization is one of the possible elements of an adaptive trial design in which the ratio of patients randomly assigned to the experimental treatment arm versus the control treatment arm changes from 1:1 over time to randomly assigning a higher proportion of patients to the arm that is doing better. Outcome-adaptive randomization has intuitive appeal in that, on average, a higher proportion of patients will be treated on the better treatment arm (if there is one). In both… CONTINUE READING
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