Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte.

  title={Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte.},
  author={Chae Hun Leem and Richard D. Vaughan-Jones},
  journal={The Journal of physiology},
  volume={509 ( Pt 2)},
1. Following an intracellular alkali load (imposed by acetate prepulsing in CO2/HCO3- buffer), intracellular pH (pHi) of the guinea-pig ventricular myocyte (recorded from intracellular SNARF fluorescence) recovers to control levels. Recovery has two phases. An initial rapid phase (lasting up to 2 min) is followed by a later slow phase (several minutes). Inhibition of sarcolemmal acid-loading carriers (by removal of extracellular Cl-) inhibits the later, slow phase but the initial rapid recovery… CONTINUE READING
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