• Corpus ID: 227918

Our Fragile Intellect

@inproceedings{Crabtree2012OurFI,
  title={Our Fragile Intellect},
  author={Gerald R. Crabtree and David Korn},
  year={2012}
}
I would be willing to wager that if an average citizen from Athens of 1000 BC were to appear suddenly among us, he or she would be among the brightest and most intellectually alive of our colleagues and companions. We would be surprised by our time-visitor’s memory, broad range of ideas and clear-sighted view of important issues. I would also guess that he or she would be among the most emotionally stable of our friends and colleagues. I do not mean to imply something special about this time in… 

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References

SHOWING 1-10 OF 34 REFERENCES

No Last Word on Language Origins

Fossils show that humans were speaking, and thinking the complex thoughts that go with speech, long before they left a plentiful record of these activities, and some archaeologists argue that there is no unequivocal evidence for modern human behavior before about 50,000 years ago.

Incest, inbreeding and mental abilities.

Two recent communications have intimated the extent of the disadvantages from which children of incestuous unions may suffer. Adams and Neel (1967) reported that of 18 offspring from unions between

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

DNA content variation (DCV) is identified as a new feature of the human brain, encompassing and further extending genomic alterations produced by aneuploidy, which may contribute to neural diversity in normal and pathophysiological states, altered functions of normal and disease‐linked genes, and differences among individuals.

Are rare variants responsible for susceptibility to complex diseases?

An explicit model for the evolution of complex disease loci is proposed, incorporating mutation, random genetic drift, and the possibility of purifying selection against susceptibility mutations, showing that, for the most plausible range of mutation rates, neutral susceptibility alleles are unlikely to be at intermediate frequencies and contribute little to the overall genetic variance for the disease.

Molecular and comparative genetics of mental retardation.

A novel test, in which unmapped MR disorders were distributed proportionately across the autosomes, failed to eliminate the well-known X-chromosome overrepresentation of MR genes and candidate genes, and a biological functions classification scheme for MR genes was developed.

Autosomal recessive mental retardation: homozygosity mapping identifies 27 single linkage intervals, at least 14 novel loci and several mutation hotspots

Novel data indicate that common molecular causes of NS-ARMR do exist, and in the Iranian population, the most frequent ones may well account for several percent of the patients.

Estimate of the mutation rate per nucleotide in humans.

Comparison of rates of evolution for X-linked and autosomal pseudogenes suggests that the male mutation rate is 4 times the female mutation rate, but provides no evidence for a reduction in mutation rate that is specific to the X chromosome.

X-linked intellectual disability: unique vulnerability of the male genome.

Progress in the clinical and molecular characterization of XLID has outpaced progress in the delineation of ID due to genes on the other 22 chromosomes, allowing for carrier testing, genetic counseling, prenatal diagnosis, and preimplantation genetic diagnosis.