Ouabain modulates epithelial cell tight junction.

  title={Ouabain modulates epithelial cell tight junction.},
  author={Isabel Larr{\'e} and Amparo L{\'a}zaro and Rub{\'e}n Gerardo Contreras and Maria Susana Balda and Karl Matter and Catalina Flores-Maldonado and Arturo Ponce and David Flores-Ben{\'i}tez and Ruth Rincon-Heredia and Teresita Padilla-Benavides and Aida M. Castillo and Liora Shoshani and Marcelino Cereijido},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 25},
Epithelial cells treated with high concentrations of ouabain (e.g., 1 microM) retrieve molecules involved in cell contacts from the plasma membrane and detach from one another and their substrates. On the basis of this observation, we suggested that ouabain might also modulate cell contacts at low, nontoxic levels (10 or 50 nM). To test this possibility, we analyzed its effect on a particular type of cell-cell contact: the tight junction (TJ). We demonstrate that at concentrations that neither… CONTINUE READING


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