Ouabain-induced changes in electrophysiologic properties of neonatal, young and adult canine cardiac Purkinje Fibers.

@article{Rosen1975OuabaininducedCI,
  title={Ouabain-induced changes in electrophysiologic properties of neonatal, young and adult canine cardiac Purkinje Fibers.},
  author={Michael R. Rosen and Allan J. Hordof and A B Hodess and M Verosky and Yvonne Vulliemoz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={194 1},
  pages={255-63}
}
Young patients frequently require higher concentrations of digitalis per kilogram of body weight or per square meter of surface area than adults to induce digitalis effect or toxicity. In order to investigate the electrophysiologic basis for this observation, we used standard microelectrode techniques to study the effects of ouabain on action potential characteristics of cardiac Purkinje fibers of neonatal (1-7 day), 4 to 7 week and adult dogs. Purkinje fibers were stimulated at a 500-msec… CONTINUE READING

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Cellular electrophysiology of digitalis toxicity.

Journal of the American College of Cardiology • 1985

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