Ouabain attenuates ovalbumin-induced airway inflammation

@article{Galvo2017OuabainAO,
  title={Ouabain attenuates ovalbumin-induced airway inflammation},
  author={J. G. Galv{\~a}o and L. H. A. Cavalcante-Silva and Deyse C M Carvalho and L. K. D. P. Ferreira and T. Monteiro and A. F. Alves and L. A. M. P. Ferreira and F. A. A. F. Gadelha and M. Piuvezam and S. Rodrigues-Mascarenhas},
  journal={Inflammation Research},
  year={2017},
  volume={66},
  pages={1117-1130}
}
PurposeOuabain, an Na+/K+-ATPase inhibitor hormone, presents immunomodulatory actions, including anti-inflammatory effect on acute inflammation models.MethodsIn the present study, the effect of ouabain in a model of allergic airway inflammation induced by ovalbumin (OVA) was assessed.ResultsInitially, it was observed that ouabain treatment inhibited cellular migration induced by OVA on bronchoalveolar lavage fluid (BALF), mostly granulocytes, without modulating macrophage migration. In addition… Expand
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