Ouabain at nanomolar concentration promotes synthesis and release of angiotensin II from the endothelium of the tail vascular bed of spontaneously hypertensive rats.

Abstract

The effects of 1 nM ouabain (OUA) on the contractile actions of phenylephrine (PHE, 0.001-100 microg) and functional activity of the sodium pump (NKA) in isolated-perfused tail vascular beds from WKY and SHR were investigated. In preparations from SHR, perfusion with OUA in the presence of endothelium (E+) increased the sensitivity (pED50) of PHE (before: 2… (More)

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@article{Padilha2004OuabainAN, title={Ouabain at nanomolar concentration promotes synthesis and release of angiotensin II from the endothelium of the tail vascular bed of spontaneously hypertensive rats.}, author={Alessandra Sim{\~a}o Padilha and Luciana Venturini Rossoni and Fabiano Elias Xavier and Dalton Valentin Vassallo}, journal={Journal of cardiovascular pharmacology}, year={2004}, volume={44 3}, pages={372-80} }